Moxidectin for Sheep
Moxidectin is used in sheep for bots, encysted cyathostomes, encysted cyathostomins, GI nematodes. Routes documented in sheep: PO, SC, TOPICAL. ExoticRx tracks Moxidectin dosing for sheep from primary veterinary literature; sign in to view the full rule set. Verify against current literature before clinical use.
Trade names: ProHeart, Advantage Multi, ProHeart 6, ProHeart 12
Dose rules — sign in to view
Cited dose rules for Moxidectin in sheep are available with a free ExoticRx account. Each row carries the route, dose range, frequency, indication, evidence level, and primary-source citation.
Mechanism of action
Binds glutamate-gated chloride channels in invertebrate nerve/muscle cells. Sustained-release formulation provides 6- or 12-month heartworm prevention.
Side effects & warnings
Caution in MDR1-mutant dogs. ProHeart injection: risk of anaphylaxis (monitor 30 min post-injection). Test for heartworm before starting. Store properly.
Species-specific contraindications and adverse-reaction reports for sheep may differ from canine / feline reference data — consult the primary citations listed with each rule.
Why a species-specific page? Moxidectin pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in sheep — the rules above are the citations specific to this species, not generic recommendations.
Sourced from primary literature; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.