Question 1

What is Milbemycin Oxime used for?

Accepted Answer

Milbemycin Oxime is indicated for: Heartworm prevention, intestinal parasites.

Question 2

What routes can Milbemycin Oxime be administered by?

Accepted Answer

Available routes: PO.

Question 3

Which species have cited Milbemycin Oxime dosing data?

Accepted Answer

Milbemycin Oxime dosing in the ExoticRx formulary covers 2 species: Cat (Domestic), Dog (Domestic).

Question 4

Is Milbemycin Oxime a controlled substance?

Accepted Answer

Milbemycin Oxime is not federally scheduled as a controlled substance, but is veterinary prescription only in most jurisdictions.

Question 5

What are the warnings or contraindications for Milbemycin Oxime?

Accepted Answer

Monthly heartworm preventative. Test for existing heartworm before starting. Use cautiously in MDR1-mutant dogs. Also effective against intestinal nematodes.

Question 6

What are the side effects of Milbemycin Oxime?

Accepted Answer

Monthly heartworm preventative. Test for existing heartworm before starting. Use cautiously in MDR1-mutant dogs. Also effective against intestinal nematodes.

Question 7

How does Milbemycin Oxime work?

Accepted Answer

Binds glutamate-gated chloride channels, causing paralysis of susceptible nematodes and arthropods.

Species	Route	Dose	Frequency	Evidence	Source
Dog (Domestic)	PO	0.5–1 mg/kg	q30d	Strong	Plumb's Veterinary Drug Handbook, 9th Ed
Cat (Domestic)	PO	2 mg/kg	q30d	Strong	Plumb's Veterinary Drug Handbook, 9th Ed

Milbemycin Oxime

Drug Class

Routes

Indications

Mechanism of Action

Side effects & warnings

Species with Milbemycin Oxime dosing data (2 dose rules)

Evidence levels across 2 dose rules

Backed by a published primary source

Sample dosing (2 of 2 cited rules)

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Other formulations of Milbemycin