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Afoxolaner-Milbemycin Oxime

NexGard Spectra

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Sourced from primary literature. Awaiting credentialed clinical reviewer — our editorial process.

Drug Class

Antiparasitic

Routes

PO

Indications

Fleasheartwormintestinal parasitesticks

Mechanism of Action

Afoxolaner (isoxazoline) blocks GABA/glutamate channels in ectoparasites; milbemycin oxime targets glutamate-gated chloride channels in nematodes. Monthly flea/tick/heartworm/dewormer.

Side effects & warnings

Dogs only. Seizure history caution (isoxazoline class). Do not use in dogs <8 weeks or <2 kg. Monthly oral. Available outside US (not FDA-approved combo in US).

Species with Afoxolaner-Milbemycin Oxime dosing data (1 dose rule)

Dog (Domestic)

Evidence levels across 1 dose rule

Strong×1

Each ExoticRx dose rule is graded by the strength of its primary evidence — see the editorial process.

Backed by a published primary source

  • · BSAVA Small Animal Formulary, 10th Ed

Sample dosing (1 of 1 cited rule)

Free-tier preview — dog and cat dosing. Pro and Student unlock all 1 species including reptiles, birds, pocket pets, livestock, and equine.

SpeciesRouteDoseFrequencyEvidenceSource
Dog (Domestic)PO0 per labelq30 daysStrongBSAVA Small Animal Formulary, 10th Ed

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Calculate Dosage for Afoxolaner-Milbemycin Oxime