ExoticRx · exoticrx.com/drugs/methylene-blue
ProvayBlue
Reduced to leucomethylene blue by NADPH-methemoglobin reductase, which then reduces methemoglobin back to functional hemoglobin.
Specific antidote for methemoglobinemia (acetaminophen toxicity in cats, nitrate/nitrite poisoning). TOXIC TO CATS at high doses (causes Heinz body anemia). Paradoxically causes methemoglobinemia at very high doses.
Each ExoticRx dose rule is graded by the strength of its primary evidence — see the editorial process.
Free-tier preview — dog and cat dosing. Pro and Student unlock all 1 species including reptiles, birds, pocket pets, livestock, and equine.
| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Dog (Domestic) | IV | 1–1.5 mg/kg | IV over 15 min, may repeat once | Moderate | Plumb's Veterinary Drug Handbook, 9th Ed |
Upgrade to Pro or Student to access full drug details including mechanism of action, warnings, dose ranges, and frequency.
View PlansSource citations and evidence levels available on the live page. Reference only — verify against current literature before clinical use.