ExoticRx · exoticrx.com/drugs/itraconazole
Sporanox, Itrafungol
Inhibits fungal 14-alpha-demethylase, blocking ergosterol synthesis. Lipophilic with high tissue concentrations.
Hepatotoxic: monitor liver enzymes. Requires acid pH for capsule absorption (give with food). Negative inotropic effect — avoid in animals with heart failure. CYP3A4 inhibitor.
Each ExoticRx dose rule is graded by the strength of its primary evidence — see the editorial process.
Free-tier preview — dog and cat dosing. Pro and Student unlock all 8 species including reptiles, birds, pocket pets, livestock, and equine.
| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Dog (Domestic) | PO | 5–10 mg/kg | q12h | Moderate | Plumb's Veterinary Drug Handbook, 9th Ed |
| Dog (Domestic) | PO | 5–10 mg/kg | q12-24h | Strong | Plumb's Veterinary Drug Handbook, 9th Ed |
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