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Hypertonic Saline

7.2% NaCl, 7.5% NaCl

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Sourced from primary literature. Awaiting credentialed clinical reviewer — our editorial process.

Drug Class

Emergency

Routes

IV

Indications

Acute hemorrhagic shockraised ICP

Mechanism of Action

Osmotically draws intracellular and interstitial water into intravascular space. Rapid small-volume resuscitation. Reduces intracranial pressure.

Side effects & warnings

Small volume resuscitation (4-5ml/kg IV over 5-10 min). Follow with isotonic crystalloids. Contraindicated in dehydration (no interstitial fluid to recruit). Monitor sodium and osmolality.

Species with Hypertonic Saline dosing data (1 dose rule)

Dog (Domestic)

Evidence levels across 1 dose rule

Moderate×1

Each ExoticRx dose rule is graded by the strength of its primary evidence — see the editorial process.

Backed by a published primary source

  • · Plumb's Veterinary Drug Handbook, 9th Ed

Sample dosing (1 of 1 cited rule)

Free-tier preview — dog and cat dosing. Pro and Student unlock all 1 species including reptiles, birds, pocket pets, livestock, and equine.

SpeciesRouteDoseFrequencyEvidenceSource
Dog (Domestic)IV4–5 ml/kg of 7.5%IV over 5-10 minModeratePlumb's Veterinary Drug Handbook, 9th Ed

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