ExoticRx · exoticrx.com/drugs/valproic-acid
Valproic Acid
Depakene, Depakote(divalproex)
Drug Class
Routes
Indications
Mechanism of Action
Increases GABA levels by inhibiting GABA transaminase and blocking voltage-gated sodium channels. Broad-spectrum anticonvulsant.
Side effects & warnings
Rapidly metabolized in dogs (very short half-life, impractical for chronic use). Hepatotoxic. Teratogenic. May cause thrombocytopenia. Limited use in veterinary medicine.
Species with Valproic Acid dosing data (1 dose rule)
Evidence levels across 1 dose rule
Each ExoticRx dose rule is graded by the strength of its primary evidence — see the editorial process.
Backed by a published primary source
- · Plumb's Veterinary Drug Handbook, 9th Ed
Sample dosing (1 of 1 cited rule)
Free-tier preview — dog and cat dosing. Pro and Student unlock all 1 species including reptiles, birds, pocket pets, livestock, and equine.
| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Dog (Domestic) | PO | 25–60 mg/kg | q8h | Weak | Plumb's Veterinary Drug Handbook, 9th Ed |
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Source citations and evidence levels available on the live page. Reference only — verify against current literature before clinical use.