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Amantadine

Symmetrel

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Sourced from primary literature. Awaiting credentialed clinical reviewer — our editorial process.

Drug Class

Neurological

Routes

PO

Indications

Chronic pain (adjunctive)Chronic pain (NMDA antagonist adjunct)

Mechanism of Action

NMDA receptor antagonist that reduces central sensitization (wind-up pain). Also has dopaminergic and antiviral activity. Used for chronic/neuropathic pain.

Side effects & warnings

Adjunctive analgesic for chronic pain (combine with NSAIDs or gabapentin). CNS excitation at high doses. Renal elimination — adjust in renal disease. GI upset.

Species with Amantadine dosing data (2 dose rules)

Cat (Domestic)Dog (Domestic)

Evidence levels across 2 dose rules

Moderate×1Weak×1

Each ExoticRx dose rule is graded by the strength of its primary evidence — see the editorial process.

Backed by a published primary source

  • · Plumb's Veterinary Drug Handbook, 9th Ed

Sample dosing (2 of 2 cited rules)

Free-tier preview — dog and cat dosing. Pro and Student unlock all 2 species including reptiles, birds, pocket pets, livestock, and equine.

SpeciesRouteDoseFrequencyEvidenceSource
Dog (Domestic)PO3–5 mg/kgq24hModeratePlumb's Veterinary Drug Handbook, 9th Ed
Cat (Domestic)PO3–5 mg/kgq24hWeakPlumb's Veterinary Drug Handbook, 9th Ed

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