ExoticRx · exoticrx.com/drugs/trimethoprim-sulfamethoxazole
Bactrim, TMS
Sequential blockade of folate synthesis: sulfamethoxazole inhibits dihydropteroate synthase; trimethoprim inhibits dihydrofolate reductase.
May cause keratoconjunctivitis sicca (KCS) in dogs with prolonged use. Can cause bone marrow suppression. Avoid in animals with hepatic disease. Adequate hydration required.
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Free-tier preview — dog and cat dosing. Pro and Student unlock all 12 species including reptiles, birds, pocket pets, livestock, and equine.
| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Dog (Domestic) | PO | 15–30 mg/kg | q12h | Moderate | Plumb's Veterinary Drug Handbook, 9th Ed |
| Dog (Domestic) | PO | 15–30 mg/kg | q12h | Strong | Plumb's Veterinary Drug Handbook, 9th Ed |
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