Question 1

What is Thiostrepton used for?

Accepted Answer

Thiostrepton is indicated for: Bacterial skin infections, otitis externa (in combination).

Question 2

What routes can Thiostrepton be administered by?

Accepted Answer

Available routes: Topical.

Question 3

Which species have cited Thiostrepton dosing data?

Accepted Answer

Thiostrepton dosing in the ExoticRx formulary covers 2 species: Cat (Domestic), Dog (Domestic).

Question 4

Is Thiostrepton a controlled substance?

Accepted Answer

Thiostrepton is not federally scheduled as a controlled substance, but is veterinary prescription only in most jurisdictions.

Question 5

What are the warnings or contraindications for Thiostrepton?

Accepted Answer

Available only in combination products (with nystatin, neomycin, triamcinolone). Topical use only. Hypersensitivity reactions possible. Do not use near eyes.

Question 6

What are the side effects of Thiostrepton?

Accepted Answer

Available only in combination products (with nystatin, neomycin, triamcinolone). Topical use only. Hypersensitivity reactions possible. Do not use near eyes.

Question 7

How does Thiostrepton work?

Accepted Answer

Thiopeptide antibiotic that binds to the 23S rRNA of the 50S ribosomal subunit, inhibiting bacterial protein synthesis. Active primarily against gram-positive bacteria.

Species	Route	Dose	Frequency	Evidence	Source
Dog (Domestic)	Topical	0 topical application	q12-24h	Strong	Panolog product label; Plumb's Veterinary Drug Handbook, 9th Ed; FDA openFDA Adverse Event Database
Cat (Domestic)	Topical	0 topical application	q12-24h	Strong	Panolog product label; Plumb's Veterinary Drug Handbook, 9th Ed; FDA openFDA Adverse Event Database

Thiostrepton

Drug Class

Routes

Indications

Mechanism of Action

Side effects & warnings

Species with Thiostrepton dosing data (2 dose rules)

Evidence levels across 2 dose rules

Backed by a published primary source

Sample dosing (2 of 2 cited rules)

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