ExoticRx · exoticrx.com/drugs/silymarin
Marin, Denamarin component, Milk Thistle, Denamarin, Milk Thistle (Silymarin)
Antioxidant and anti-inflammatory flavonoid from milk thistle. Stabilizes hepatocyte membranes, stimulates protein synthesis, and scavenges free radicals.
Generally safe. Often combined with SAMe (Denamarin). Evidence for hepatoprotection moderate. GI upset at high doses. May interact with P-glycoprotein substrates.
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Free-tier preview — dog and cat dosing. Pro and Student unlock all 4 species including reptiles, birds, pocket pets, livestock, and equine.
| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Dog (Domestic) | PO | 5–10 mg/kg | q24h | Moderate | Plumb's Veterinary Drug Handbook, 9th Ed |
| Dog (Domestic) | PO | 20–50 mg/kg | q24h (divided q8-12h preferred) | Moderate | Plumb's Veterinary Drug Handbook, 9th Ed |
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