ExoticRx · exoticrx.com/drugs/sarolaner-moxidectin-pyrantel
Simparica Trio
Sarolaner (isoxazoline) inhibits GABA/glutamate channels in ectoparasites; moxidectin (macrocyclic lactone) targets nematode glutamate-gated chloride channels; pyrantel depolarizes nematode NMJ.
Dogs only. Seizure risk in dogs with MDR1 mutation (moxidectin component). Do not use in dogs <8 weeks or <2.8 lbs. Monthly oral administration.
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Free-tier preview — dog and cat dosing. Pro and Student unlock all 1 species including reptiles, birds, pocket pets, livestock, and equine.
| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Dog (Domestic) | PO | 0 per label | q30 days | Strong | Plumb's Veterinary Drug Handbook, 9th Ed |
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View PlansSource citations and evidence levels available on the live page. Reference only — verify against current literature before clinical use.