ExoticRx · exoticrx.com/drugs/sarolaner
Simparica, component of Simparica Trio
Potent isoxazoline that inhibits GABA and glutamate-gated chloride channels in arthropod nervous system. Monthly flea, tick, and mite protection.
Seizure potential in dogs with neurologic history. Not for use in puppies <6 months. Effective against Demodex and Sarcoptes mites.
Each ExoticRx dose rule is graded by the strength of its primary evidence — see the editorial process.
Free-tier preview — dog and cat dosing. Pro and Student unlock all 1 species including reptiles, birds, pocket pets, livestock, and equine.
| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Dog (Domestic) | PO | 2–4 mg/kg | q30 days | Strong | Plumb's Veterinary Drug Handbook, 9th Ed |
| Dog (Domestic) | PO | 2–4 mg/kg | q30 days | Moderate | Plumb's Veterinary Drug Handbook, 9th Ed |
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View PlansSource citations and evidence levels available on the live page. Reference only — verify against current literature before clinical use.