ExoticRx · exoticrx.com/drugs/s-adenosylmethionine
Denosyl, SAMe
Methyl donor and precursor to glutathione synthesis. Supports hepatocellular glutathione levels, membrane fluidity, and antioxidant defense. Also has anti-inflammatory properties.
Give on empty stomach (food reduces absorption by 70%). Enteric coating must not be broken. Well-tolerated. Used for hepatic support and as antioxidant. Not a substitute for specific hepatic therapy.
Each ExoticRx dose rule is graded by the strength of its primary evidence — see the editorial process.
Free-tier preview — dog and cat dosing. Pro and Student unlock all 2 species including reptiles, birds, pocket pets, livestock, and equine.
| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Dog (Domestic) | PO | 20 mg/kg | q24h | Moderate | Plumb's Veterinary Drug Handbook, 9th Ed |
| Dog (Domestic) | PO | 20–40 mg/kg | q24h on empty stomach | Moderate | Plumb's Veterinary Drug Handbook, 9th Ed |
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View PlansSource citations and evidence levels available on the live page. Reference only — verify against current literature before clinical use.