Question 1

What is Romifidine used for?

Accepted Answer

Romifidine is indicated for: Sedation (off-label).

Question 2

What routes can Romifidine be administered by?

Accepted Answer

Available routes: IV.

Question 3

Which species have cited Romifidine dosing data?

Accepted Answer

Romifidine dosing in the ExoticRx formulary covers 2 species: Cat (Domestic), Dog (Domestic).

Question 4

Is Romifidine a controlled substance?

Accepted Answer

Romifidine is not federally scheduled as a controlled substance, but is veterinary prescription only in most jurisdictions.

Question 5

What are the warnings or contraindications for Romifidine?

Accepted Answer

Primarily equine. Bradycardia, initial hypertension then hypotension. Reversible with atipamezole. Second-degree AV block common.

Question 6

What are the side effects of Romifidine?

Accepted Answer

Primarily equine. Bradycardia, initial hypertension then hypotension. Reversible with atipamezole. Second-degree AV block common.

Question 7

How does Romifidine work?

Accepted Answer

Alpha-2 adrenergic agonist causing sedation, analgesia, and muscle relaxation. Less ataxia than xylazine and detomidine. Primarily equine use.

Species	Route	Dose	Frequency	Evidence	Source
Dog (Domestic)	IV	0.02–0.04 mg/kg	Single dose	Extrapolated	Plumb's Veterinary Drug Handbook, 9th Ed
Cat (Domestic)	IV	0.02–0.04 mg/kg	Single dose	Extrapolated	Plumb's Veterinary Drug Handbook, 9th Ed

Romifidine

Drug Class