ExoticRx · exoticrx.com/drugs/diazepam
Valium
Enhances GABA-A receptor activity by binding the benzodiazepine site, increasing chloride ion conductance, producing sedation, anxiolysis, muscle relaxation, and anticonvulsant effects.
HEPATOTOXICITY in cats (oral use — acute hepatic necrosis, sometimes fatal). Short duration in dogs (rapid redistribution). Avoid IM (erratic absorption). Reversible with flumazenil. Controlled substance.
Controlled substance
Each ExoticRx dose rule is graded by the strength of its primary evidence — see the editorial process.
Free-tier preview — dog and cat dosing. Pro and Student unlock all 6 species including reptiles, birds, pocket pets, livestock, and equine.
| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Dog (Domestic) | IV | 0.5–2 mg/kg | q5 min (max 3 doses) | Strong | Plumb's Veterinary Drug Handbook, 9th Ed |
| Dog (Domestic) | RECTAL | 0.5–2 mg/kg | q5 min (max 3 doses) | Strong | Plumb's Veterinary Drug Handbook, 9th Ed |
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