Skip to main content

Perampanel

Fycompa

Calculate dosage
Sourced from primary literature. Awaiting credentialed clinical reviewer — our editorial process.

Drug Class

Neurological

Routes

PO

Indications

Refractory epilepsy (AMPA antagonist)Refractory seizures

Mechanism of Action

First-in-class selective non-competitive AMPA-type glutamate receptor antagonist. Reduces excitatory glutamatergic neurotransmission.

Side effects & warnings

Aggression and hostility reported. Dose-related dizziness and somnolence. Schedule III controlled substance. No veterinary pharmacokinetic data published.

Species with Perampanel dosing data (2 dose rules)

Cat (Domestic)Dog (Domestic)

Controlled Substance

Controlled substance

Evidence levels across 2 dose rules

Anecdotal×2

Each ExoticRx dose rule is graded by the strength of its primary evidence — see the editorial process.

Backed by a published primary source

  • · Plumb's Veterinary Drug Handbook, 9th Ed

Sample dosing (2 of 2 cited rules)

Free-tier preview — dog and cat dosing. Pro and Student unlock all 2 species including reptiles, birds, pocket pets, livestock, and equine.

SpeciesRouteDoseFrequencyEvidenceSource
Dog (Domestic)PO0.5–2 mg/kgq24hAnecdotalPlumb's Veterinary Drug Handbook, 9th Ed
Cat (Domestic)PO0.25–1 mg/kgq24hAnecdotalPlumb's Veterinary Drug Handbook, 9th Ed

Upgrade for Full Details

Upgrade to Pro or Student to access full drug details including mechanism of action, warnings, dose ranges, and frequency.

View Plans

More Neurological drugs

Calculate Dosage for Perampanel