Question 1

What is Oritavancin used for?

Accepted Answer

Oritavancin is indicated for: Resistant gram-positive infections, Resistant gram-positive skin infections.

Question 2

What routes can Oritavancin be administered by?

Accepted Answer

Available routes: IV.

Question 3

Which species have cited Oritavancin dosing data?

Accepted Answer

Oritavancin dosing in the ExoticRx formulary covers 2 species: Cat (Domestic), Dog (Domestic).

Question 4

Is Oritavancin a controlled substance?

Accepted Answer

Oritavancin is not federally scheduled as a controlled substance, but is veterinary prescription only in most jurisdictions.

Question 5

What are the warnings or contraindications for Oritavancin?

Accepted Answer

Interferes with coagulation tests (aPTT) for up to 120 hours. Infusion reactions possible. Single-dose regimen. No veterinary data.

Question 6

What are the side effects of Oritavancin?

Accepted Answer

Interferes with coagulation tests (aPTT) for up to 120 hours. Infusion reactions possible. Single-dose regimen. No veterinary data.

Question 7

How does Oritavancin work?

Accepted Answer

Triple mechanism: inhibits transglycosylation, transpeptidation, and disrupts bacterial membrane integrity. Bactericidal against gram-positives including MRSA/VRE.

Species	Route	Dose	Frequency	Evidence	Source
Dog (Domestic)	IV	15–20 mg/kg	Single dose	Weak	Plumb's Veterinary Drug Handbook, 9th Ed
Cat (Domestic)	IV	15–20 mg/kg	Single dose	Weak	Plumb's Veterinary Drug Handbook, 9th Ed

Oritavancin

Drug Class

Routes

Indications

Mechanism of Action

Side effects & warnings

Species with Oritavancin dosing data (2 dose rules)

Evidence levels across 2 dose rules

Backed by a published primary source

Sample dosing (2 of 2 cited rules)

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