Skip to main content

Olanzapine

Zyprexa

Calculate dosage
Sourced from primary literature. Awaiting credentialed clinical reviewer — our editorial process.

Drug Class

Behavioral

Routes

PO

Indications

aggressionSevere compulsive disorderSevere psychogenic alopecia refractory to SSRIs

Mechanism of Action

Antagonist at serotonin 5-HT2A/2C, dopamine D1-D4, muscarinic M1-M5, histamine H1, and alpha-1 adrenergic receptors. Broad receptor binding profile.

Side effects & warnings

Weight gain and metabolic syndrome common. Sedation, especially at initiation. Risk of hepatotoxicity. Very limited veterinary data.

Species with Olanzapine dosing data (2 dose rules)

Cat (Domestic)Dog (Domestic)

Evidence levels across 2 dose rules

Anecdotal×2

Each ExoticRx dose rule is graded by the strength of its primary evidence — see the editorial process.

Backed by 2 published primary sources

  • · Crowell-Davis SL, Veterinary Psychopharmacology, 2nd Ed
  • · Plumb's Veterinary Drug Handbook, 9th Ed

Sample dosing (2 of 2 cited rules)

Free-tier preview — dog and cat dosing. Pro and Student unlock all 2 species including reptiles, birds, pocket pets, livestock, and equine.

SpeciesRouteDoseFrequencyEvidenceSource
Dog (Domestic)PO0.25–0.5 mg/kgq24hAnecdotalCrowell-Davis SL, Veterinary Psychopharmacology, 2nd Ed
Cat (Domestic)PO0.1–0.25 mg/kgq24hAnecdotalPlumb's Veterinary Drug Handbook, 9th Ed

Upgrade for Full Details

Upgrade to Pro or Student to access full drug details including mechanism of action, warnings, dose ranges, and frequency.

View Plans

More Behavioral drugs

Calculate Dosage for Olanzapine