ExoticRx · exoticrx.com/drugs/lotilaner
Lotilaner
Credelio
Drug Class
Routes
Indications
Mechanism of Action
Isoxazoline ectoparasiticide blocking GABA and glutamate-gated chloride channels. Monthly flea and tick protection.
Side effects & warnings
Seizure potential in dogs with history of neurologic disorders. Administer with food. Not for use in puppies <8 weeks or <1.4kg.
Species with Lotilaner dosing data (2 dose rules)
Evidence levels across 2 dose rules
Each ExoticRx dose rule is graded by the strength of its primary evidence — see the editorial process.
Backed by a published primary source
- · Plumb's Veterinary Drug Handbook, 9th Ed
Sample dosing (2 of 2 cited rules)
Free-tier preview — dog and cat dosing. Pro and Student unlock all 1 species including reptiles, birds, pocket pets, livestock, and equine.
| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Dog (Domestic) | PO | 20–43 mg/kg | q30 days | Strong | Plumb's Veterinary Drug Handbook, 9th Ed |
| Dog (Domestic) | PO | 20–43 mg/kg | q30 days | Moderate | Plumb's Veterinary Drug Handbook, 9th Ed |
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Source citations and evidence levels available on the live page. Reference only — verify against current literature before clinical use.