Question 1

What is Loperamide used for?

Accepted Answer

Loperamide is indicated for: Acute noninfectious diarrhea, Non-infectious diarrhea.

Question 2

What routes can Loperamide be administered by?

Accepted Answer

Available routes: PO.

Question 3

Which species have cited Loperamide dosing data?

Accepted Answer

Loperamide dosing in the ExoticRx formulary covers 1 species: Dog (Domestic).

Question 4

Is Loperamide a controlled substance?

Accepted Answer

Loperamide is not federally scheduled as a controlled substance, but is veterinary prescription only in most jurisdictions.

Question 5

What are the warnings or contraindications for Loperamide?

Accepted Answer

CONTRAINDICATED in MDR1-mutant dogs (crosses BBB — severe CNS depression). Avoid in cats. Do not use in infectious diarrhea. May cause constipation, bloating, ileus.

Question 6

What are the side effects of Loperamide?

Accepted Answer

CONTRAINDICATED in MDR1-mutant dogs (crosses BBB — severe CNS depression). Avoid in cats. Do not use in infectious diarrhea. May cause constipation, bloating, ileus.

Question 7

How does Loperamide work?

Accepted Answer

Mu-opioid receptor agonist in GI tract, slowing motility and increasing segmental contractions. Increases fluid/electrolyte absorption.

Species	Route	Dose	Frequency	Evidence	Source
Dog (Domestic)	PO	0.08–0.2 mg/kg	q8-12h	Moderate	Plumb's Veterinary Drug Handbook, 9th Ed
Dog (Domestic)	PO	0.1–0.2 mg/kg	q8-12h	Moderate	Plumb's Veterinary Drug Handbook, 9th Ed

Loperamide

Drug Class

Routes

Indications

Mechanism of Action

Side effects & warnings

Species with Loperamide dosing data (2 dose rules)

Evidence levels across 2 dose rules

Backed by a published primary source

Sample dosing (2 of 2 cited rules)

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