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Lamotrigine

Lamictal

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Sourced from primary literature. Awaiting credentialed clinical reviewer — our editorial process.

Drug Class

Neurological

Routes

PO

Indications

Refractory epilepsyRefractory seizures

Mechanism of Action

Blocks voltage-sensitive sodium channels, stabilizing neuronal membranes and inhibiting glutamate release. Also modulates high-voltage-activated calcium channels.

Side effects & warnings

Risk of serious dermatologic reactions (Stevens-Johnson syndrome). Must titrate dose slowly. Very limited veterinary data. Monitor for skin rashes.

Species with Lamotrigine dosing data (2 dose rules)

Cat (Domestic)Dog (Domestic)

Evidence levels across 2 dose rules

Anecdotal×2

Each ExoticRx dose rule is graded by the strength of its primary evidence — see the editorial process.

Backed by a published primary source

  • · Plumb's Veterinary Drug Handbook, 9th Ed

Sample dosing (2 of 2 cited rules)

Free-tier preview — dog and cat dosing. Pro and Student unlock all 2 species including reptiles, birds, pocket pets, livestock, and equine.

SpeciesRouteDoseFrequencyEvidenceSource
Dog (Domestic)PO2–5 mg/kgq12hAnecdotalPlumb's Veterinary Drug Handbook, 9th Ed
Cat (Domestic)PO1–3 mg/kgq12hAnecdotalPlumb's Veterinary Drug Handbook, 9th Ed

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Calculate Dosage for Lamotrigine