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Indoxacarb

Activyl

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Sourced from primary literature. Awaiting credentialed clinical reviewer — our editorial process.

Drug Class

Antiparasitic

Routes

TOPICAL

Indications

Flea control

Mechanism of Action

Bioactivated by flea enzymes to its active metabolite, which blocks sodium channels causing paralysis and death. Flea-activated (low mammalian toxicity).

Side effects & warnings

Dogs and cats. Monthly topical. Safe for puppies/kittens >8 weeks. May take 8 hours for full flea kill. Lower environmental flea burden important.

Species with Indoxacarb dosing data (2 dose rules)

Cat (Domestic)Dog (Domestic)

Evidence levels across 2 dose rules

Moderate×2

Each ExoticRx dose rule is graded by the strength of its primary evidence — see the editorial process.

Backed by a published primary source

  • · Plumb's Veterinary Drug Handbook, 9th Ed

Sample dosing (2 of 2 cited rules)

Free-tier preview — dog and cat dosing. Pro and Student unlock all 2 species including reptiles, birds, pocket pets, livestock, and equine.

SpeciesRouteDoseFrequencyEvidenceSource
Dog (Domestic)TOPICAL0 weight-based pipetteq30 daysModeratePlumb's Veterinary Drug Handbook, 9th Ed
Cat (Domestic)TOPICAL0 weight-based pipetteq30 daysModeratePlumb's Veterinary Drug Handbook, 9th Ed

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