Question 1

What is Fluoxetine used for?

Accepted Answer

Fluoxetine is indicated for: aggression, compulsive disorders, compulsive grooming, Separation anxiety, Urine marking.

Question 2

What routes can Fluoxetine be administered by?

Accepted Answer

Available routes: PO.

Question 3

Which species have cited Fluoxetine dosing data?

Accepted Answer

Fluoxetine dosing in the ExoticRx formulary covers 2 species: Cat (Domestic), Dog (Domestic).

Question 4

Is Fluoxetine a controlled substance?

Accepted Answer

Fluoxetine is not federally scheduled as a controlled substance, but is veterinary prescription only in most jurisdictions.

Question 5

What are the warnings or contraindications for Fluoxetine?

Accepted Answer

Reconcile FDA-approved for canine separation anxiety. 4-6 weeks for full effect. Serotonin syndrome risk with tramadol, MAOIs, TCAs. Reduced appetite, lethargy initially. Long half-life.

Question 6

What are the side effects of Fluoxetine?

Accepted Answer

Reconcile FDA-approved for canine separation anxiety. 4-6 weeks for full effect. Serotonin syndrome risk with tramadol, MAOIs, TCAs. Reduced appetite, lethargy initially. Long half-life.

Question 7

How does Fluoxetine work?

Accepted Answer

Selectively inhibits serotonin reuptake at the presynaptic membrane, increasing serotonergic neurotransmission.

Species	Route	Dose	Frequency	Evidence	Source
Dog (Domestic)	PO	1–2 mg/kg	q24h	Strong	Plumb's Veterinary Drug Handbook, 9th Ed
Cat (Domestic)	PO	0.5–1.5 mg/kg	q24h	Moderate	Plumb's Veterinary Drug Handbook, 9th Ed

Fluoxetine

Drug Class

Routes

Indications

Mechanism of Action

Side effects & warnings

Species with Fluoxetine dosing data (2 dose rules)

Evidence levels across 2 dose rules

Backed by a published primary source

Sample dosing (2 of 2 cited rules)

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