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Fipronil-S-Methoprene

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Sourced from primary literature. Awaiting credentialed clinical reviewer — our editorial process.

Drug Class

Antiparasitic

Routes

TOPICAL

Indications

Fleas and ticks

Mechanism of Action

Fipronil blocks GABA-gated chloride channels in arthropod CNS; S-methoprene is an insect growth regulator (IGR) preventing flea egg/larval development.

Side effects & warnings

Dogs and cats. Monthly topical. TOXIC to rabbits. Do not use on rabbits. Keep away from aquatic environments. Apply to dry skin.

Species with Fipronil-S-Methoprene dosing data (2 dose rules)

Cat (Domestic)Dog (Domestic)

Evidence levels across 2 dose rules

Strong×2

Each ExoticRx dose rule is graded by the strength of its primary evidence — see the editorial process.

Backed by a published primary source

  • · Plumb's Veterinary Drug Handbook, 9th Ed

Sample dosing (2 of 2 cited rules)

Free-tier preview — dog and cat dosing. Pro and Student unlock all 2 species including reptiles, birds, pocket pets, livestock, and equine.

SpeciesRouteDoseFrequencyEvidenceSource
Dog (Domestic)TOPICAL0 weight-based pipetteq30 daysStrongPlumb's Veterinary Drug Handbook, 9th Ed
Cat (Domestic)TOPICAL0 weight-based pipetteq30 daysStrongPlumb's Veterinary Drug Handbook, 9th Ed

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