Question 1

What is Esomeprazole used for?

Accepted Answer

Esomeprazole is indicated for: Acute GI bleeding, Gastric acid suppression, stress ulceration.

Question 2

What routes can Esomeprazole be administered by?

Accepted Answer

Available routes: PO, IV.

Question 3

Which species have cited Esomeprazole dosing data?

Accepted Answer

Esomeprazole dosing in the ExoticRx formulary covers 2 species: Cat (Domestic), Dog (Domestic).

Question 4

Is Esomeprazole a controlled substance?

Accepted Answer

Esomeprazole is not federally scheduled as a controlled substance, but is veterinary prescription only in most jurisdictions.

Question 5

What are the warnings or contraindications for Esomeprazole?

Accepted Answer

More bioavailable than omeprazole. IV form available for acute GI bleeding. Long-term use may affect calcium/magnesium absorption. Rebound acid hypersecretion on discontinuation.

Question 6

What are the side effects of Esomeprazole?

Accepted Answer

More bioavailable than omeprazole. IV form available for acute GI bleeding. Long-term use may affect calcium/magnesium absorption. Rebound acid hypersecretion on discontinuation.

Question 7

How does Esomeprazole work?

Accepted Answer

S-isomer of omeprazole. Irreversibly inhibits H+/K+ ATPase (proton pump) in gastric parietal cells. More predictable pharmacokinetics than omeprazole.

Species	Route	Dose	Frequency	Evidence	Source
Dog (Domestic)	IV	0.5–1 mg/kg	q12-24h	Moderate	Plumb's Veterinary Drug Handbook, 9th Ed
Dog (Domestic)	PO	0.5–1 mg/kg	q12-24h	Moderate	Plumb's Veterinary Drug Handbook, 9th Ed

Esomeprazole

Drug Class

Routes

Indications

Mechanism of Action

Side effects & warnings

Species with Esomeprazole dosing data (3 dose rules)

Evidence levels across 3 dose rules

Backed by a published primary source

Sample dosing (2 of 3 cited rules)

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