Question 1

What is Eluxadoline used for?

Accepted Answer

Eluxadoline is indicated for: Chronic diarrhea, Diarrhea-predominant IBS.

Question 2

What routes can Eluxadoline be administered by?

Accepted Answer

Available routes: PO.

Question 3

Which species have cited Eluxadoline dosing data?

Accepted Answer

Eluxadoline dosing in the ExoticRx formulary covers 2 species: Cat (Domestic), Dog (Domestic).

Question 4

Is Eluxadoline a controlled substance?

Accepted Answer

Eluxadoline is not federally scheduled as a controlled substance, but is veterinary prescription only in most jurisdictions.

Question 5

What are the warnings or contraindications for Eluxadoline?

Accepted Answer

Contraindicated in pancreatitis or biliary obstruction. Sphincter of Oddi spasm risk. Limited to no veterinary data.

Question 6

What are the side effects of Eluxadoline?

Accepted Answer

Contraindicated in pancreatitis or biliary obstruction. Sphincter of Oddi spasm risk. Limited to no veterinary data.

Question 7

How does Eluxadoline work?

Accepted Answer

Mixed mu-opioid receptor agonist, delta-opioid antagonist, and kappa-opioid agonist acting locally in the enteric nervous system to reduce GI motility and visceral pain.

Species	Route	Dose	Frequency	Evidence	Source
Dog (Domestic)	PO	0.5–1.5 mg/kg	q12h	Extrapolated	Veterinary Gastroenterology Literature Review
Cat (Domestic)	PO	0.5–1 mg/kg	q12h	Extrapolated	Veterinary Gastroenterology Literature Review

Eluxadoline

Drug Class

Routes

Indications

Mechanism of Action

Side effects & warnings

Species with Eluxadoline dosing data (2 dose rules)

Evidence levels across 2 dose rules

Backed by a published primary source

Sample dosing (2 of 2 cited rules)

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