Question 1

What is Domperidone used for?

Accepted Answer

Domperidone is indicated for: Gastroparesis, GER.

Question 2

What routes can Domperidone be administered by?

Accepted Answer

Available routes: PO.

Question 3

Which species have cited Domperidone dosing data?

Accepted Answer

Domperidone dosing in the ExoticRx formulary covers 2 species: Cat (Domestic), Dog (Domestic).

Question 4

Is Domperidone a controlled substance?

Accepted Answer

Domperidone is not federally scheduled as a controlled substance, but is veterinary prescription only in most jurisdictions.

Question 5

What are the warnings or contraindications for Domperidone?

Accepted Answer

Does not cross blood-brain barrier (fewer CNS effects than metoclopramide). QT prolongation risk. Used in horses for fescue toxicosis to restore lactation.

Question 6

What are the side effects of Domperidone?

Accepted Answer

Does not cross blood-brain barrier (fewer CNS effects than metoclopramide). QT prolongation risk. Used in horses for fescue toxicosis to restore lactation.

Question 7

How does Domperidone work?

Accepted Answer

Peripheral dopamine D2 receptor antagonist. Enhances GI motility and increases lower esophageal sphincter pressure. Also increases prolactin release.

Species	Route	Dose	Frequency	Evidence	Source
Dog (Domestic)	PO	0.1–0.3 mg/kg	q8h	Moderate	Plumb's Veterinary Drug Handbook, 9th Ed
Cat (Domestic)	PO	0.1–0.3 mg/kg	q8h	Weak	Plumb's Veterinary Drug Handbook, 9th Ed

Domperidone

Drug Class

Routes

Indications

Mechanism of Action

Side effects & warnings

Species with Domperidone dosing data (2 dose rules)

Evidence levels across 2 dose rules

Backed by a published primary source

Sample dosing (2 of 2 cited rules)

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