ExoticRx · exoticrx.com/drugs/diethylcarbamazine
Filaribits, DEC
Sensitizes microfilariae to host immune attack. Exact mechanism unclear; may involve inhibition of arachidonic acid metabolism in parasites.
CONTRAINDICATED in heartworm-positive dogs (anaphylaxis from microfilaria die-off). Must test negative before starting. Daily dosing required. Largely replaced by monthly preventatives.
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| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Dog (Domestic) | PO | 6.6 mg/kg | q24h | Strong | Plumb's Veterinary Drug Handbook, 9th Ed |
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