Question 1

What is Dapsone used for?

Accepted Answer

Dapsone is indicated for: Immune-mediated skin disease (pemphigus, vasculitis), Sterile neutrophilic dermatosis (Sweet syndrome).

Question 2

What routes can Dapsone be administered by?

Accepted Answer

Available routes: PO, Topical.

Question 3

Which species have cited Dapsone dosing data?

Accepted Answer

Dapsone dosing in the ExoticRx formulary covers 1 species: Dog (Domestic).

Question 4

Is Dapsone a controlled substance?

Accepted Answer

Dapsone is not federally scheduled as a controlled substance, but is veterinary prescription only in most jurisdictions.

Question 5

What are the warnings or contraindications for Dapsone?

Accepted Answer

Methemoglobinemia and hemolytic anemia risk, especially in cats. Monitor CBC regularly. Hepatotoxic. Screen for G6PD deficiency when possible.

Question 6

What are the side effects of Dapsone?

Accepted Answer

Methemoglobinemia and hemolytic anemia risk, especially in cats. Monitor CBC regularly. Hepatotoxic. Screen for G6PD deficiency when possible.

Question 7

How does Dapsone work?

Accepted Answer

Inhibits neutrophil myeloperoxidase and chemotaxis. Suppresses the alternative complement pathway. Also has antibacterial activity against Mycobacterium leprae.

Species	Route	Dose	Frequency	Evidence	Source
Dog (Domestic)	PO	1 mg/kg	q8h initially, then q12h maintenance	Moderate	Miller WH, Small Animal Dermatology, 7th Ed
Dog (Domestic)	PO	1 mg/kg	q8h	Weak	Miller WH, Small Animal Dermatology, 7th Ed

Dapsone

Drug Class

Routes

Indications

Mechanism of Action

Side effects & warnings

Species with Dapsone dosing data (2 dose rules)

Evidence levels across 2 dose rules

Backed by a published primary source

Sample dosing (2 of 2 cited rules)

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