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Cloxacillin

Orbenin, Dry-Clox

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Sourced from primary literature. Awaiting credentialed clinical reviewer — our editorial process.

Drug Class

Antibiotic

Routes

POIMIntramammary

Indications

Staphylococcal infectionsStaphylococcal skin and soft tissue infections

Mechanism of Action

Inhibits bacterial cell wall synthesis by binding to PBPs. Resistant to staphylococcal penicillinase, providing targeted activity against penicillinase-producing Staphylococcus spp.

Side effects & warnings

Cross-allergenicity with other beta-lactams. GI upset common with oral administration. Primarily used for staphylococcal mastitis in cattle.

Species with Cloxacillin dosing data (2 dose rules)

Cat (Domestic)Dog (Domestic)

Evidence levels across 2 dose rules

Extrapolated×2

Each ExoticRx dose rule is graded by the strength of its primary evidence — see the editorial process.

Backed by a published primary source

  • · Plumb's Veterinary Drug Handbook, 9th Ed; FDA openFDA Adverse Event Database

Sample dosing (2 of 2 cited rules)

Free-tier preview — dog and cat dosing. Pro and Student unlock all 2 species including reptiles, birds, pocket pets, livestock, and equine.

SpeciesRouteDoseFrequencyEvidenceSource
Dog (Domestic)PO20–40 mg/kgq8hExtrapolatedPlumb's Veterinary Drug Handbook, 9th Ed; FDA openFDA Adverse Event Database
Cat (Domestic)PO20–40 mg/kgq8hExtrapolatedPlumb's Veterinary Drug Handbook, 9th Ed; FDA openFDA Adverse Event Database

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Calculate Dosage for Cloxacillin