Question 1

What is Clomipramine used for?

Accepted Answer

Clomipramine is indicated for: anxiety, compulsive disorders, Separation anxiety, Urine spraying.

Question 2

What routes can Clomipramine be administered by?

Accepted Answer

Available routes: PO.

Question 3

Which species have cited Clomipramine dosing data?

Accepted Answer

Clomipramine dosing in the ExoticRx formulary covers 2 species: Cat (Domestic), Dog (Domestic).

Question 4

Is Clomipramine a controlled substance?

Accepted Answer

Clomipramine is not federally scheduled as a controlled substance, but is veterinary prescription only in most jurisdictions.

Question 5

What are the warnings or contraindications for Clomipramine?

Accepted Answer

FDA-approved for separation anxiety in dogs. 2-4 weeks for effect. GI upset, sedation, urinary retention. CONTRAINDICATED with MAOIs. Serotonin syndrome risk. Lower seizure threshold.

Question 6

What are the side effects of Clomipramine?

Accepted Answer

FDA-approved for separation anxiety in dogs. 2-4 weeks for effect. GI upset, sedation, urinary retention. CONTRAINDICATED with MAOIs. Serotonin syndrome risk. Lower seizure threshold.

Question 7

How does Clomipramine work?

Accepted Answer

Potent serotonin and norepinephrine reuptake inhibitor. More serotonin-selective than amitriptyline. Also has anticholinergic properties.

Species	Route	Dose	Frequency	Evidence	Source
Dog (Domestic)	PO	1–3 mg/kg	q12h	Strong	Plumb's Veterinary Drug Handbook, 9th Ed
Cat (Domestic)	PO	0.25–0.5 mg/kg	q24h	Moderate	Plumb's Veterinary Drug Handbook, 9th Ed

Clomipramine

Drug Class

Routes

Indications

Mechanism of Action

Side effects & warnings

Species with Clomipramine dosing data (2 dose rules)

Evidence levels across 2 dose rules

Backed by a published primary source

Sample dosing (2 of 2 cited rules)

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