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Ceftolozane-Tazobactam

Zerbaxa

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Sourced from primary literature. Awaiting credentialed clinical reviewer — our editorial process.

Drug Class

Antibiotic

Routes

IV

Indications

MDR gram-negative infectionsMDR Pseudomonas infections

Mechanism of Action

Ceftolozane binds PBPs with high affinity; tazobactam protects against beta-lactamase degradation. Enhanced Pseudomonas activity.

Side effects & warnings

Renal dose adjustment required. GI upset common. Very limited veterinary data — reserve for resistant infections.

Species with Ceftolozane-Tazobactam dosing data (2 dose rules)

Cat (Domestic)Dog (Domestic)

Evidence levels across 2 dose rules

Weak×2

Each ExoticRx dose rule is graded by the strength of its primary evidence — see the editorial process.

Backed by a published primary source

  • · Plumb's Veterinary Drug Handbook, 9th Ed

Sample dosing (2 of 2 cited rules)

Free-tier preview — dog and cat dosing. Pro and Student unlock all 2 species including reptiles, birds, pocket pets, livestock, and equine.

SpeciesRouteDoseFrequencyEvidenceSource
Dog (Domestic)IV20–40 mg/kgq8hWeakPlumb's Veterinary Drug Handbook, 9th Ed
Cat (Domestic)IV20–40 mg/kgq8hWeakPlumb's Veterinary Drug Handbook, 9th Ed

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