Question 1

What is Cefiderocol used for?

Accepted Answer

Cefiderocol is indicated for: MDR gram-negative infections, MDR gram-negative infections (CRE, CR-Pseudomonas).

Question 2

What routes can Cefiderocol be administered by?

Accepted Answer

Available routes: IV.

Question 3

Which species have cited Cefiderocol dosing data?

Accepted Answer

Cefiderocol dosing in the ExoticRx formulary covers 2 species: Cat (Domestic), Dog (Domestic).

Question 4

Is Cefiderocol a controlled substance?

Accepted Answer

Cefiderocol is not federally scheduled as a controlled substance, but is veterinary prescription only in most jurisdictions.

Question 5

What are the warnings or contraindications for Cefiderocol?

Accepted Answer

Renal dose adjustment. Higher mortality in CR-Acinetobacter in one study. Reserve for MDR gram-negatives. No veterinary data.

Question 6

What are the side effects of Cefiderocol?

Accepted Answer

Renal dose adjustment. Higher mortality in CR-Acinetobacter in one study. Reserve for MDR gram-negatives. No veterinary data.

Question 7

How does Cefiderocol work?

Accepted Answer

Chelates iron to gain entry via bacterial iron transport systems (Trojan horse). Binds PBPs once inside. Stable against all classes of beta-lactamases.

Species	Route	Dose	Frequency	Evidence	Source
Dog (Domestic)	IV	30–60 mg/kg	q8h	Weak	Plumb's Veterinary Drug Handbook, 9th Ed
Cat (Domestic)	IV	30–60 mg/kg	q8h	Weak	Plumb's Veterinary Drug Handbook, 9th Ed

Cefiderocol

Drug Class

Routes

Indications

Mechanism of Action

Side effects & warnings

Species with Cefiderocol dosing data (2 dose rules)

Evidence levels across 2 dose rules

Backed by a published primary source

Sample dosing (2 of 2 cited rules)

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