ExoticRx · exoticrx.com/drugs/zoledronic-acid
Zometa, Reclast
Most potent bisphosphonate available. Inhibits farnesyl diphosphate synthase in mevalonate pathway disrupting osteoclast function.
Single IV infusion. Used for hypercalcemia of malignancy and bone metastases in dogs. Nephrotoxic — ensure adequate hydration. Jaw osteonecrosis rare. Acute phase reaction (fever, myalgia).
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Free-tier preview — dog and cat dosing. Pro and Student unlock all 1 species including reptiles, birds, pocket pets, livestock, and equine.
| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Dog (Domestic) | IV | 0.1–0.25 mg/kg | once q28 days | Moderate | Plumb's Veterinary Drug Handbook, 9th Ed |
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