ExoticRx · exoticrx.com/drugs/trilostane
Vetoryl
Competitively inhibits 3-beta-hydroxysteroid dehydrogenase, blocking conversion of pregnenolone to progesterone, thereby reducing cortisol synthesis.
First-line for canine Cushing's disease. Monitor with ACTH stimulation test. Adrenal necrosis reported (rare but serious). Hypoadrenocorticism risk. Give with food. Not for use in cats or pregnant animals.
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Free-tier preview — dog and cat dosing. Pro and Student unlock all 1 species including reptiles, birds, pocket pets, livestock, and equine.
| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Dog (Domestic) | PO | 1–2.5 mg/kg | q12h | Strong | Plumb's Veterinary Drug Handbook, 9th Ed |
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