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Tildipirosin (Long-Acting) for Cattle

Tildipirosin (Long-Acting) is used in cattle for Bovine respiratory disease. Routes documented in cattle: SC. ExoticRx tracks Tildipirosin (Long-Acting) dosing for cattle from primary veterinary literature; sign in to view the full rule set. Verify against current literature before clinical use.

Trade names: Zuprevo

Dose rules — sign in to view

Cited dose rules for Tildipirosin (Long-Acting) in cattle are available with a free ExoticRx account. Each row carries the route, dose range, frequency, indication, evidence level, and primary-source citation.

Sources include: FDA NADA Label

Mechanism of action

16-membered ring macrolide that inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit. Concentrates extensively in lung tissue.

Side effects & warnings

SC injection in the posterior aspect of the ear only in cattle. Fatal if injected IV. Not for use in female dairy cattle 20 months of age or older.

Species-specific contraindications and adverse-reaction reports for cattle may differ from canine / feline reference data — consult the primary citations listed with each rule.

Why a species-specific page? Tildipirosin (Long-Acting) pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in cattle — the rules above are the citations specific to this species, not generic recommendations.

Sourced from primary literature; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.