Ponazuril (Livestock) for Cattle
Ponazuril (Livestock) is used in cattle for Coccidiosis in calves, EPM (Sarcocystis neurona), Equine protozoal myeloencephalitis (EPM). Routes documented in cattle: PO. ExoticRx tracks Ponazuril (Livestock) dosing for cattle from primary veterinary literature; sign in to view the full rule set. Verify against current literature before clinical use.
Trade names: Toltrazuril Sulfone
Dose rules — sign in to view
Cited dose rules for Ponazuril (Livestock) in cattle are available with a free ExoticRx account. Each row carries the route, dose range, frequency, indication, evidence level, and primary-source citation.
Mechanism of action
Active metabolite of toltrazuril. Inhibits mitochondrial enzyme systems in coccidia, disrupting nuclear division and mitochondrial function in all intracellular stages.
Side effects & warnings
Extra-label use in livestock. Primarily used in calves and lambs for coccidiosis treatment and prevention. Long half-life allows single-dose protocols.
Species-specific contraindications and adverse-reaction reports for cattle may differ from canine / feline reference data — consult the primary citations listed with each rule.
Why a species-specific page? Ponazuril (Livestock) pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in cattle — the rules above are the citations specific to this species, not generic recommendations.
Sourced from primary literature; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.