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Poloxamer 407

Pluronic F-127

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Sourced from primary literature. Awaiting credentialed clinical reviewer — our editorial process.

Drug Class

Compounded

Routes

TRANSDERMAL

Indications

Vehicle

Mechanism of Action

Thermoreversible poloxamer gel that is liquid at cold temperatures and gels at body temperature. Used as vehicle for transdermal drug delivery of various active ingredients.

Side effects & warnings

Compounding vehicle, not active drug. Systemic bioavailability of drugs in PLO gel is variable and often unpublished. Not all drugs are suitable for transdermal delivery. Ear pinna application common in cats.

Species with Poloxamer 407 dosing data (2 dose rules)

Cat (Domestic)Dog (Domestic)

Evidence levels across 2 dose rules

Moderate×2

Each ExoticRx dose rule is graded by the strength of its primary evidence — see the editorial process.

Backed by a published primary source

  • · Plumb's Veterinary Drug Handbook, 9th Ed

Sample dosing (2 of 2 cited rules)

Free-tier preview — dog and cat dosing. Pro and Student unlock all 2 species including reptiles, birds, pocket pets, livestock, and equine.

SpeciesRouteDoseFrequencyEvidenceSource
Dog (Domestic)TRANSDERMAL0 per labelPer active drug scheduleModeratePlumb's Veterinary Drug Handbook, 9th Ed
Cat (Domestic)TRANSDERMAL0 per labelPer active drug scheduleModeratePlumb's Veterinary Drug Handbook, 9th Ed

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