ExoticRx · exoticrx.com/drugs/methylprednisolone-acetate-injectable
Methylprednisolone Acetate Injectable
Depo-Medrol
Drug Class
Routes
Indications
Mechanism of Action
Depot formulation providing prolonged glucocorticoid effect lasting 2-6 weeks. Suppresses inflammation and immune-mediated conditions.
Side effects & warnings
Prolonged adrenal suppression. Cannot titrate dose once injected. Risk of iatrogenic Cushing's with repeated use. Diabetogenic in cats.
Species with Methylprednisolone Acetate Injectable dosing data (2 dose rules)
Evidence levels across 2 dose rules
Each ExoticRx dose rule is graded by the strength of its primary evidence — see the editorial process.
Backed by a published primary source
- · Plumb's Veterinary Drug Handbook, 9th Ed
Sample dosing (2 of 2 cited rules)
Free-tier preview — dog and cat dosing. Pro and Student unlock all 2 species including reptiles, birds, pocket pets, livestock, and equine.
| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Dog (Domestic) | IM | 1–2 mg/kg | Once; may repeat in 2-6 weeks if needed | Strong | Plumb's Veterinary Drug Handbook, 9th Ed |
| Cat (Domestic) | IM | 2–5 mg/kg | Once; may repeat q4-8 weeks if needed | Strong | Plumb's Veterinary Drug Handbook, 9th Ed |
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Source citations and evidence levels available on the live page. Reference only — verify against current literature before clinical use.