ExoticRx · exoticrx.com/drugs/levetiracetam
Keppra
Binds synaptic vesicle protein SV2A, modulating neurotransmitter release. Novel mechanism distinct from other anticonvulsants. Does not affect GABA or sodium channels at therapeutic doses.
Excellent safety profile. Minimal hepatic metabolism (renal excretion). No significant drug interactions. Sedation and ataxia initially (usually transient). Use extended-release if available (q12h instead of q8h). Safe in cats.
Each ExoticRx dose rule is graded by the strength of its primary evidence — see the editorial process.
Free-tier preview — dog and cat dosing. Pro and Student unlock all 3 species including reptiles, birds, pocket pets, livestock, and equine.
| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Dog (Domestic) | IV | 20–60 mg/kg | Loading dose IV over 5-10 min | Strong | Plumb's Veterinary Drug Handbook, 9th Ed |
| Dog (Domestic) | PO | 20–60 mg/kg | q8h (IR) or q12h (ER) | Strong | Plumb's Veterinary Drug Handbook, 9th Ed |
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