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Eprinomectin (Pour-On) for Cattle

Eprinomectin (Pour-On) is used in cattle for GI nematodes, grubs, Internal and external parasites, lice. Routes documented in cattle: Topical (pour-on). ExoticRx tracks Eprinomectin (Pour-On) dosing for cattle from primary veterinary literature; sign in to view the full rule set. Verify against current literature before clinical use.

Trade names: Eprinex, Ivomec Eprinex

Dose rules — sign in to view

Cited dose rules for Eprinomectin (Pour-On) in cattle are available with a free ExoticRx account. Each row carries the route, dose range, frequency, indication, evidence level, and primary-source citation.

Sources include: FDA NADA Label

Mechanism of action

Macrocyclic lactone that potentiates glutamate-gated chloride channels in nematode and arthropod nerve/muscle cells, causing paralysis and death of parasites.

Side effects & warnings

Zero-day milk and meat withdrawal in dairy cattle at label dose — unique advantage over other avermectins. For topical application along the backline. Not for use in calves under 200 lbs intended for veal.

Species-specific contraindications and adverse-reaction reports for cattle may differ from canine / feline reference data — consult the primary citations listed with each rule.

Why a species-specific page? Eprinomectin (Pour-On) pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in cattle — the rules above are the citations specific to this species, not generic recommendations.

Sourced from primary literature; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.