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Digestive Enzyme Supplement (Pancrelipase)

Viokase, PanaKare Plus, Creon Vet

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Sourced from primary literature. Awaiting credentialed clinical reviewer — our editorial process.

Drug Class

Supplement

Routes

PO

Indications

Exocrine pancreatic insufficiencyExocrine pancreatic insufficiency (EPI)

Mechanism of Action

Porcine-derived lipase, amylase, and protease enzymes that replace deficient pancreatic secretions, enabling digestion and absorption of fats, carbohydrates, and proteins.

Side effects & warnings

Mix with food immediately before feeding. May cause oral ulceration if not mixed well. High doses may cause diarrhea. Enzyme potency varies between products.

Species with Digestive Enzyme Supplement (Pancrelipase) dosing data (2 dose rules)

Cat (Domestic)Dog (Domestic)

Evidence levels across 2 dose rules

Strong×2

Each ExoticRx dose rule is graded by the strength of its primary evidence — see the editorial process.

Backed by 2 published primary sources

  • · Plumb's Veterinary Drug Handbook, 9th Ed
  • · Plumb's Veterinary Drug Handbook, 9th Ed; ACVIM Consensus on EPI

Sample dosing (2 of 2 cited rules)

Free-tier preview — dog and cat dosing. Pro and Student unlock all 2 species including reptiles, birds, pocket pets, livestock, and equine.

SpeciesRouteDoseFrequencyEvidenceSource
Dog (Domestic)PO1–2 tsp/20kg/mealWith each mealStrongPlumb's Veterinary Drug Handbook, 9th Ed; ACVIM Consensus on EPI
Cat (Domestic)PO0.5–1 tsp per mealWith each mealStrongPlumb's Veterinary Drug Handbook, 9th Ed

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Calculate Dosage for Digestive Enzyme Supplement (Pancrelipase)