ExoticRx · exoticrx.com/drugs/clodronate
Osphos
Inhibits osteoclast-mediated bone resorption by being incorporated into ATP analogs that are cytotoxic to osteoclasts. Reduces pathological bone remodeling and associated pain.
FDA-approved for horses with navicular syndrome. Renal toxicity possible at high doses. May cause GI signs, colic, or transient discomfort post-injection. Limited small animal data.
Each ExoticRx dose rule is graded by the strength of its primary evidence — see the editorial process.
Free-tier preview — dog and cat dosing. Pro and Student unlock all 1 species including reptiles, birds, pocket pets, livestock, and equine.
| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Dog (Domestic) | SC | 20–25 mg/kg | Single dose or monthly | Weak | JAVMA; FDA openFDA Adverse Event Database |
Upgrade to Pro or Student to access full drug details including mechanism of action, warnings, dose ranges, and frequency.
View PlansSource citations and evidence levels available on the live page. Reference only — verify against current literature before clinical use.