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Cephapirin (Intramammary Dry Cow) for Cattle

Cephapirin (Intramammary Dry Cow) is used in cattle for Dry cow mastitis therapy, Mastitis (lactating and dry cow). Routes documented in cattle: Intramammary. ExoticRx tracks Cephapirin (Intramammary Dry Cow) dosing for cattle from primary veterinary literature; sign in to view the full rule set. Verify against current literature before clinical use.

Trade names: ToDAY, ToMORROW

Dose rules — sign in to view

Cited dose rules for Cephapirin (Intramammary Dry Cow) in cattle are available with a free ExoticRx account. Each row carries the route, dose range, frequency, indication, evidence level, and primary-source citation.

Sources include: FDA NADA Label

Mechanism of action

First-generation cephalosporin that inhibits bacterial cell wall synthesis. Lactating and dry cow formulations provide local antimicrobial activity within the mammary gland.

Side effects & warnings

For intramammary use in dairy cattle only. Lactating cow formulation: 96-hour milk withdrawal, 4-day meat withdrawal. Dry cow formulation: not for use within 30 days of calving.

Species-specific contraindications and adverse-reaction reports for cattle may differ from canine / feline reference data — consult the primary citations listed with each rule.

Why a species-specific page? Cephapirin (Intramammary Dry Cow) pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in cattle — the rules above are the citations specific to this species, not generic recommendations.

Sourced from primary literature; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.