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Acepromazine (Livestock) for Cattle

Acepromazine (Livestock) is used in cattle for pre-anesthetic, Pre-anesthetic sedation, preanesthetic, Sedation. Routes documented in cattle: IV, IM. ExoticRx tracks Acepromazine (Livestock) dosing for cattle from primary veterinary literature; sign in to view the full rule set. Verify against current literature before clinical use.

Trade names: PromAce, Atravet

Dose rules — sign in to view

Cited dose rules for Acepromazine (Livestock) in cattle are available with a free ExoticRx account. Each row carries the route, dose range, frequency, indication, evidence level, and primary-source citation.

Sources include: Plumb's Veterinary Drug Handbook; Plumb's Veterinary Drug Handbook, 9th Ed

Mechanism of action

Phenothiazine derivative that blocks postsynaptic dopamine receptors in the CNS, producing sedation and reducing anxiety. Also has antiemetic and mild antihistaminic effects.

Side effects & warnings

Causes hypotension by alpha-1 adrenergic blockade. Do not use in stallions (penile prolapse risk). No analgesic properties. Avoid in hypovolemic or debilitated animals. Long duration of action.

Species-specific contraindications and adverse-reaction reports for cattle may differ from canine / feline reference data — consult the primary citations listed with each rule.

Why a species-specific page? Acepromazine (Livestock) pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in cattle — the rules above are the citations specific to this species, not generic recommendations.

Sourced from primary literature; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.